Sharing links are not available for this article. Additionally, diabetes poses a major risk for cardiovascular disease, both by itself and through its association with other risk factors such as hypertension and dyslipidaemia.2, Insulin is used for intensive treatment in type 1 diabetes and in insulin-requiring type 2 diabetes when oral agents do not achieve adequate glycaemic control. The levels of intracellular ROS production and antioxidant capacity were significantly increased and decreased, respectively, in KGN cells after treatment with high concentrations of BPA and its analogues. Creams, ointments, and lotions to relieve symptoms from the skin; It is known that furniture is made of natural wood or chipboard; it is a constant source of formaldehyde. In the Elecsys® E170 assay, relevant cross-reactivity was only detected with insulin glargine, whereas in the other analysers all analogues except glulisine showed significant interference. Bimatoprost, latanoprost, and travoprost are synthetic prostaglandin analogues. Regarding the Immulite® 2000 analyser, the percentage differences with respect to the control sample were: aspart 1636.1%, glargine 1541.7%, and lispro 1431.8%. They affect the following classes: Being that during allergic reactions intoxication occurs, the person must urgently visit the doctor-toxicologist. Subscribe to newsletters for the latest medication news, new drug approvals, alerts and updates. Increasing concentrations of aspart, glargine, and lispro showed increased interference in Immulite® 2000. Strategies combining basal and bolus insulin treatments are often applied to achieve more physiological insulin profiles and to maintain long-term glycaemic control,3 using insulin analogues synthesized by recombinant DNA technology.4, Currently available insulin analogues include fast-acting preparations: insulin aspart, insulin lispro, and insulin glulisine. Applies to: Liver Disease, Renal Dysfunction. We found that in Advia Centaur®, the concentrations measured were higher than in the other two analysers. The aim of this study was to determine the interference caused by the new analogues (lispro, aspart, detemir, glargine, and glulisine) in three different automated analysers. It is widely employed in various types of industry, and, in fact, is an indispensable segment of a great diversity of things and objects. Science 10 Jul 1931: Vol. Results of the study of interference depending on the concentration of analogue in the Immulite® 2000 analyser. Moderate Potential Hazard, Moderate plausibility. These were diluted using 7% fetal bovine serum (FBS) to concentrations of 10,000 mIU/L each, 10 times higher than the maximum concentration studied. Data sources include IBM Watson Micromedex (updated 2 Nov 2020), Cerner Multum™ (updated 2 Nov 2020), ASHP (updated 23 Oct 2020) and others. All authors reviewed and edited the manuscript and approved the final version of the manuscript. The interferent (insulin analogue) solutions prepared beforehand were then diluted 10-fold using this pool, thus obtaining our working solutions. 28–29) but glulisine also has a modification at the amino-terminal end of that chain (aa. Epub 2015 Mar 16. In addition, we found that the damage to biomacromolecules, which are the main targets of oxidative stress was significantly increased after treatment with BPA, BPS, BPF, and BPAF. AD wrote the first draft of the manuscript. The means and standard deviations of the sample concentrations obtained with each analyser are shown in Table 1. Usually avoid combinations; use it only under special circumstances. Macular edema, including cystoid macular edema, has been reported during treatment with ophthalmic prostaglandin analogues. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. Toward standardization of insulin immunoassays, An automated, high-throughput method for targeted quantification of intact insulin and its therapeutic analogs in human serum or plasma coupling mass spectrometric immunoassay with high resolution and accurate mass detection (MSIA-HR/AM), Cross-reactivity of three recombinant insulin analogs with five commercial insulin immunoassays, Cross-reactivity of 12 recombinant insulin preparations in the Beckman Unicel DxI 800 insulin assay, Elecsys insulin assay: free insulin determination and the absence of cross-reactivity with insulin lispro, Comparison of 11 human insulin assays: implications for clinical investigation and research, Variability in cross-reactivity of novel insulin analogues in immunometric insulin assays, Insulin inmunoassays in the detection of insulin analogues in factitious hypoglycemia, Comisión de efectos de los medicamentos en química clínica. Prevalencia de la Diabetes en España: Estudio. Interference was observed to increase linearly in the case of glargine in both Elecsys® E170 and Immulite® 2000, or exponentially in the cases of aspart and lispro in Immulite® 2000, with increasing concentrations of analogue. However, an increase in the concentration of serum insulin did not increase the cross-reactivity. Select one or more newsletters to continue. What is formaldehyde? It is a preservative in the manufacture of skin care products, hygiene goods, paints, detergents; it is added to medicines and it is the constituent of balsaming solution. Also, mass spectrometry-based methods for insulin analogue assessment have been described, although their use is not widespread.9, Immunometric assays have recently shown higher specificity than radioimmunoassays in the detection of human insulin. In the gastrointestinal tract acute pain in the abdomen, nausea, vomiting, diarrhea are noticed. For the study of interference dependent on the base concentration of insulin, a multiple linear regression model was used including the following variables: insulin concentration, concentration of the analogue, and the product of both or insulin-analogue interaction term.

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