I saw the liquid SAM-e on iherb, i could order it, but you did mention once that it helps with liver but maybe not the joins, so now I'm not sure. It's used for many different things in people- liver supplement, depression, arthritis, ect. My 1 year old Dane has multiple liver shunts and had been taking Denamarin until my vet recommended this: 175 mg Milk Thistle - available at health food stores - 1/day 200 IU vitamin E - 1/day 200 IU SAMe - 1/day 300 mg Ursodiol -2/day - this one you'll need a prescription for from your vet If you choose an alternative to Denamarin, make sure you aren’t getting a milk thistle supplement formulated for humans. Denamarin ® Advanced Chewable Tablets should be given on an empty stomach, at least one hour before a meal for optimal absorption. SAMe (Denosyl, Denamarin) is actually a human medication that we use in dogs. Hello, Denamarin contains S-Adenosylmethionine and is supposed to help the liver in dogs and is used in supplements for humans as well. Milk thistle created just for pets has more accurate dosing directions and warnings. trolled clinical trial in alcoholic liver disease in humans. S-Adenosylmethionine (SAMe) is a naturally occurring compound that is found in almost every tissue and fluid in the body. Denamarin’s active ingredients individually have been shown to be safe and effective for both dogs and cats in published research studies. Pets have different needs than humans and using a supplement created for human consumption can lead to improper dosing. I would not induce vomiting. The number of chewable tablets administered may be gradually reduced, or increased, at any time at the recommendation of your veterinarian. However, if treated quickly it is possible to prevent liver disease from developing with supplemental nutrition. Denosyl or Denamarin plus shipping would cost me $2.50 a pill and for 2 dogs.. quite abit there especially if I could give an alternative with human ones. Its progression to irreversible and terminal liver cirrhosis happens quickly, preceded by jaundice, anemia, brain dysfunction, and internal bleeding. I hope this helps. Most likely nothing will happen after taking the Denamarin. Denamarin contains a specific silybin shown to provide better bioavailability in dogs compared to the standardized milk thistle commonly available in health food stores and over-the-counter in pharmacies. 25 Denamarin is a commercially available veterinary product containing a stable salt of SAMe and silybin in a phosphatidylcholine complex, both with established bio-availability in dogs.a,26,27 A one time ingestion is not something I would worry about, although I am not an MD so consulting with your physician would be the best thing to do. The Difference Between Denamarin and Denosyl | EntirelyPets - Liver disease is deadly if left untreated in pets.

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